Lia Therapeutics

An image of Sinéad Buckley of Lia Therapeutics
Logo of

Sinéad Buckley, Lia Therapeutics

A drug-free, wearable medical device to treat dry and sore eyes.

What problem are you solving and what is innovative about your approach?

“I’ve tried everything and still I wake up every morning with a stinging sensation in my eye, it feels as if my eyelid is stuck to my eye, I can’t go on like this”. The surface of the eye, the most sensitive part of the body, needs a constant tear film over 24 hours to maintain a healthy eye. Patients who do not generate this tear film adequately are diagnosed as suffering with Dry Eye Disease. The absence of the tear film results in patient symptoms of grittiness, pain and vision impairment through the day and more so, often patients wake up 3-4 times a night coinciding with the REM sleep phase, when the rapidly moving dry eye will grate off the closed eyelid.

The Nightleaf™ innovative mechanism of action (neuromodulation) continuously replenishes the natural tear film to:

  • alleviate symptoms both overnight and during the day,
  • reduce further damage to the surface of the eye, 
  • heal the surface of the eye and
  • re-engage the nerves to work as intended over the full 24 hours.

How is this idea commercially attractive?

There are estimated to be 340 million people suffering from Dry Eye Disease globally, 34 million of them in the US alone. Of these people in the US, 17 million of them are diagnosed and are seeking treatment. Only 13% of patients experience lasting relief from their treatments for Dry Eye Disease. Patients are spending an average out-of-pocket cost of $1,050 per year. And up to 92% of patients at night-time are either putting viscous ointments into their eyes or moisture chamber sealed goggles over their eyes. Nightleaf™ worn overnight will be a proven, clinically effective, patient-centred treatment.

What do you hope to achieve by participating in Big Ideas?

By participating in Big Ideas, Lia Therapeutics will seize the opportunity to connect with people who want to join us in our mission to help everyone with dry and sore eyes.